Top 10 Mewtwo Pokémon Cards to Collect

Collector guide · Reviewed 21 October 2026 · By TCGInvest editorial

Mewtwo’s card history moves between solitary portraits, laboratory imagery and partnerships with Mew. That gives a species collection more range than simply selecting the newest full art. This list follows several of those ideas across early holos, lowercase ex cards, uppercase EX designs and modern GX illustrations.

Affiliate disclosure: This guide contains eBay affiliate links. TCGInvest may earn a commission if you buy through them. Links open searches, not guaranteed stock or offers; check the exact listing before buying.

How we chose these cards

This is an editorial shortlist ranked for artwork, variety across card designs and usefulness in a themed collection. It is not a price, rarity, popularity-vote or expected-return ranking. We focus on established English printings from several eras, rather than promising a complete catalogue or every recent release. Edition and foil variants are not separate places unless explicitly identified. The pictured finish is a reference: confirm the finish offered by the seller.

Start with a comparison: Open Card Finder to look for the printing and inspect any available dated references. Coverage varies, so a missing card or price is not a zero valuation. See how our sources work.

The shortlist at a glance

1. Mewtwo-GX — Shining Legends

Exact printing: Mewtwo-GX · Shining Legends · 78/73 · English.

The Shining Legends laboratory illustration gives Mewtwo a clear story and a strong sense of atmosphere. It is an appealing centrepiece for collectors interested in the Pokémon's origins. Number 78 is essential because other Mewtwo-GX cards in the expansion use different artwork.

Search eBay UK for Mewtwo-GX 78/73 · Compare the pictured edition, finish, condition and delivered price before choosing a listing.

2. Mewtwo — Base

Exact printing: Mewtwo · Base · 10/102 · English.

Base Set Mewtwo is the historical starting point for an English collection. Its older holo layout gives a useful contrast to the cinematic modern cards. Compare the same edition and shadow treatment, and ask for foil close-ups when a seller describes a copy as near mint.

Search eBay UK for Mewtwo 10/102 · Compare the pictured edition, finish, condition and delivered price before choosing a listing.

3. Shining Mewtwo — Neo Destiny

Exact printing: Shining Mewtwo · Neo Destiny · 109/105 · English.

Shining Mewtwo brings an alternate colour treatment into the Neo-era design. It suits a collection that follows shiny Pokémon or pairs Mewtwo with Shining Mew. Check the edition stamp and exact number; a modern shiny GX card is a different printing with different comparison points.

Search eBay UK for Shining Mewtwo 109/105 · Compare the pictured edition, finish, condition and delivered price before choosing a listing.

4. Mewtwo-EX — Next Destinies

Exact printing: Mewtwo-EX · Next Destinies · 98/99 · English.

Next Destinies' full-art Mewtwo-EX represents a major change in visual style from the early holos. It is useful for a collection organised by card mechanics. Match number 98 rather than the regular Mewtwo-EX, and inspect the textured surface and border.

Search eBay UK for Mewtwo-EX 98/99 · Compare the pictured edition, finish, condition and delivered price before choosing a listing.

5. Mewtwo ex — Ruby & Sapphire

Exact printing: Mewtwo ex · Ruby & Sapphire · 101/109 · English.

Ruby & Sapphire Mewtwo ex is an early lowercase ex-era entry with a silver border. It bridges the vintage layout and later full-card designs. The suffix matters: Mewtwo ex and Mewtwo-EX belong to different card systems and should not be conflated in a search.

Search eBay UK for Mewtwo ex 101/109 · Compare the pictured edition, finish, condition and delivered price before choosing a listing.

6. Rocket's Mewtwo ex — Team Rocket Returns

Exact printing: Rocket's Mewtwo ex · Team Rocket Returns · 99/109 · English.

Rocket's Mewtwo ex connects the species with Team Rocket's darker visual identity. It makes a strong pairing with Rocket's Mewtwo from Gym Challenge. Search for Team Rocket Returns and number 99, and ask for original photographs if a listing only shows a stock scan.

Search eBay UK for Rocket's Mewtwo ex 99/109 · Compare the pictured edition, finish, condition and delivered price before choosing a listing.

7. Mewtwo ★ — Holon Phantoms

Exact printing: Mewtwo ★ · Holon Phantoms · 103/110 · English.

The Holon Phantoms star-marked Mewtwo is a separate shiny-era collecting target. It provides a different design direction from the laboratory scene. The star and collector number are useful safeguards against broad search results containing unrelated Mewtwo cards, proxies or mixed-card bundles.

Search eBay UK for Mewtwo ★ 103/110 · Compare the pictured edition, finish, condition and delivered price before choosing a listing.

8. Mewtwo-EX — BREAKthrough

Exact printing: Mewtwo-EX · BREAKthrough · 164/162 · English.

BREAKthrough's secret-numbered Mewtwo-EX gives the collection a busy, battle-oriented composition. It works if you enjoy comparing the multiple Mewtwo treatments within one expansion. Match number 164 and the artwork, rather than accepting a listing described only as a secret Mewtwo.

Search eBay UK for Mewtwo-EX 164/162 · Compare the pictured edition, finish, condition and delivered price before choosing a listing.

9. Mewtwo & Mew-GX — Unified Minds

Exact printing: Mewtwo & Mew-GX · Unified Minds · 222/236 · English.

The full-art Mewtwo & Mew-GX puts the two related Pokémon on a shared TAG TEAM card. It is a natural bridge between separate Mew and Mewtwo pages. Number 222 is the full-art target; the standard and rainbow versions are different entries.

Search eBay UK for Mewtwo & Mew-GX 222/236 · Compare the pictured edition, finish, condition and delivered price before choosing a listing.

10. Rocket's Mewtwo — Gym Challenge

Exact printing: Rocket's Mewtwo · Gym Challenge · 14/132 · English.

Rocket's Mewtwo adds a Trainer-linked identity within the Gym Challenge layout. It offers a focused vintage alternative to Base Set without duplicating that artwork. Check the edition, foil and English set name before comparing a raw copy with a graded example.

Search eBay UK for Rocket's Mewtwo 14/132 · Compare the pictured edition, finish, condition and delivered price before choosing a listing.

Build a Mewtwo collection with a clear goal

Choose between an origins-and-laboratory theme, a Team Rocket pairing or a timeline of card mechanics. If collecting Mewtwo alongside Mew, record a shared TAG TEAM card once in your ownership list instead of accidentally treating the two species pages as two separate purchases.

Use the tools before you choose a listing

Identify and compare: Card Finder helps you look for exact cards and available observations. Check the date and source market before treating a reference as a UK transaction price.

Review a graded card: PSA Lookup is a useful next step when checking a PSA-labelled listing. Match the label, certificate and card photographs; a certificate number by itself does not establish the condition or authenticity of the item offered.

Consider grading carefully: Read our UK grading costs and turnaround guide before submitting a card. Check the current service terms, include postage and selling costs, and allow for uncertain grades. A raw-to-PSA-10 price difference is not expected profit.

Explore the set: Browse chase cards when you want context for other cards in an expansion. If you are comparing sealed products as well, use the Booster Box Tracker and ETB Tracker. A set reference is not the price of this single card. For a sealed purchase you already track, use the ROI Calculator to compare its recorded performance with your purchase cost; it is a sealed-product tool, not a card-grading forecast.

Keep track: Where a card is covered, open its detail page to use the available collection or watchlist controls. See price-alert options for supported products; coverage, account requirements and plan limits apply. An article link does not mean every card here has an alert.

How to compare eBay listings

Start with the exact name, set, number and English language shown above. Our links use the card name, set and collector number, with English selected through eBay’s language filter. Promotional cards use their specific promo number rather than a long set label. Search results can still include the wrong printing, bundles or altered cards. They are starting points, not a seller recommendation or an authentication service.

For vintage cards, compare the edition stamp and any relevant printing differences. For all cards, ask for clear front, back, corner and surface photographs. A scan of the ideal card does not establish the condition of the copy for sale. Holo, reverse-holo, stamped and non-holo variants may share a number.

Compare the total delivered cost, including postage and any import charges. Raw and graded copies belong in separate comparisons, as do different grading companies and grades. Asking prices are not completed-sale evidence. Read the seller’s description, feedback and return terms before committing.

Questions about collecting Mewtwo cards

Which Mewtwo card should I buy first?

Choose one artwork you would enjoy owning, then set a delivered-cost limit. The first-ranked card is an editorial display pick, not a requirement or a promise that it is affordable. A simpler set card can make a better first purchase if you prefer its artwork or condition.

Are these the most expensive Mewtwo cards?

No. The order reflects this guide’s collecting criteria. It does not use a live price table, auction record, print-run estimate or measured popularity score. A card outside this list can be a better fit for your theme.

Should I buy a single card or open packs?

A correctly identified single lets you choose the specific card and condition offered. Opening packs has an uncertain outcome and does not guarantee any card on this list. Compare the experience you want with the money you are prepared to spend.

Do the eBay links show the exact card?

They search for the card name, set and number, with English selected through eBay’s language filter, but eBay can return imperfect matches. Verify the listing photographs, language, finish and condition yourself. We do not claim current stock, a particular seller or a fixed price.

Sources and artwork

Card names, set identities, numbers and reference artwork were checked against the Pokémon TCG data catalogue, an independent community-maintained dataset. Images are served from copies checked against TCGdex’s English card catalogue or Pokémon’s official card artwork. You can also consult the official Pokémon card database and its search guide. Older releases and variants may need separate references. Card artwork is © Pokémon / Nintendo / Creatures / GAME FREAK; displayed to identify and discuss the cards, without implying endorsement. Rankings and collecting commentary are TCGInvest editorial choices.

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